do we know enough about the long-term effects of hrt to be sure it's safe and will live up to the claims made for it?

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do we know enough about the long-term effects of hrt to be sure it's safe and will live up to the claims made for it?
DO WE KNOW ENOUGH ABOUT THE LONG-TERM EFFECTS OF HRT TO BE SURE IT'S SAFE AND WILL LIVE UP TO THE CLAIMS MADE FOR IT?
One area of concern is a possible increased risk of breast cancer in women on HRT for more than ten years. This is an issue that many research teams are investigating.
Another area of uncertainty is the effect on heart disease risk of including progestogens in HRT formats. It seems that while progestogens protect the endometrium, they may also reduce the protective effects of oestrogen on blood fats when used in large doses. The 19-nortestosterone progestogens seem to have a more adverse effect than the more commonly prescribed Provera in this regard.
It is also unclear what effects long-term use of progestogens (high or low dose) have on women. Studies are under way in many medical and research centres worldwide, including several in Australia, but we won't know the answer to this question until the end of this decade.
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